Individualized predictive signatures for 5-fluorouracil-based chemotherapy in right- and left-sided colon cancer
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چکیده
منابع مشابه
Laterality: Right-Sided and Left-Sided Colon Cancer
Colorectal cancer (CRC) can be characterized by the location of the primary tumor being within the colon [1]. Right-sided colon cancer (RCC) is derived from the embryologic midgut, including the proximal two-thirds of the transverse colon, ascending colon, and cecum. Left-sided colon cancer (LCC) is derived from the embryologic hindgut, which includes the distal third of the transverse colon, s...
متن کاملRight-sided vs left-sided colorectal cancer.
AV In the analysis of the Cancer and Leukemia Group B (CALGB)/SWOG 80405 trial that we presented at the 2016 annual meeting of the American Society of Clinical Oncology (ASCO), we defined right-sided colon cancer as cancer of the cecum and the ascending colon up to the hepatic flexure. Left-sided colon cancer comprises cancer of the splenic flexure and cancer in regions distal to the splenic fl...
متن کاملCalcitriol Supplementation Causes Decreases in Tumorigenic Proteins and Different Proteomic and Metabolomic Signatures in Right versus Left-Sided Colon Cancer
Vitamin D deficiency is a common problem worldwide. In particular, it is an issue in the Northern Hemisphere where UVB radiation does not penetrate the atmosphere as readily. There is a correlation between vitamin D deficiency and colorectal cancer incidence and mortality. Furthermore, there is strong evidence that cancer of the ascending (right side) colon is different from cancer of the desce...
متن کاملA nationwide Danish cohort study challenging the categorisation into right-sided and left-sided colon cancer
OBJECTIVES The categorisation of colon cancer (CC) into right-sided (RCC) and left-sided (LCC) disease may not capture more subtle variances in aetiology and prognosis. In a nationwide study, we investigated differences in clinical characteristics and survival of RCC versus LCC and of the complete range of CC subsites. DESIGN Prospective nationwide cohort study. SETTING The database of the ...
متن کاملRight-sided colon cancer and left-sided colorectal cancers respond differently to cetuximab.
INTRODUCTION Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated with the response to cetuximab in patients with metastatic colorectal cancer (mCRC). METHODS Patients with mCRC treated with cetuximab and standard chemotherapy as first- or...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2018
ISSN: 1347-9032
DOI: 10.1111/cas.13622